In this comedy movie, the two potheads unknowingly smuggle a van made of marijuana into Mexico while being chased by the inept  Sgt. Stedenko (Stacey Keach). While not much was expected from this flick, Up in Smoke ended up making over $100 million worldwide and thrust Cheech & Chong into the mainstream. It’s also really great to watch when high. 

3. Pineapple Express (2008)

The comedy writing team of Seth Rogen and Evan Goldberg (with some help from Judd Apatow) delivers an action-comedy anyone can enjoy, high or not. Directed by David Gordon Green (Halloween, Haloween Kills), Pineapple Express is about a couple of stoner losers who witness a murder by corrupt cops and are forced on the run.

This movie has plenty of laughs that match the all-star cast that includes Rogen, Danny McBride, James Franco, Gary Cole, Amber Heard, Rosie Perez, and Craig Robinson. The film also has a top-notch soundtrack with songs from Huey Lewis and the News, Cypress Hill, Spiritualized, and Peter Tosh.

A sequel was rumored to be happening but got canned over budget disagreements. Despite this, Pineapple Express stands alone as a fantastic and funny movie.

4. Harold & Kumar Go To Whitecastle (2004)

Here is another classic weed flick that developed a cult following after its release in 2004. Harold Lee (John Cho) and Kumar Patel (Kal Penn) embark on an adventure to the fast-food chain Whitecastle after getting high. What follows is a madcap series of events that sees the two best friends attacked by a raccoon, propositioned by a man named Freakshow, ride an escaped cheetah, and have a run-in with police after Kumar accidentally punches a cop. Neil Patrick Harris also stars as himself, high on ecstasy.

A lot happens in Harold & Kumar Go To Whitecastle as the two’s quest for a delish burger is constantly interrupted. Although the film spawned two sequels (neither are very good), you can’t go past the original when it comes to a modern stoner comedy.